In 2005, he made a cameo in the film Next of Kin. In 2007, Tyler appeared in Cold Case and Rock ville CA, a webseries launched by Josh Schwartz. In 2010, he appeared on Days of Our Lives, Gigantic, and was also in the independent film Peach Plum Pear.
In October 2010, Blackburn was cast in a recurring role as the dashing and street smart Caleb Rivers in the TV series Pretty Little Liars. He was upgraded to series regular for the third season starting in the summer of 2012. He is the only cast member to be added as a series regular since the pilot.
I March 2011, he joined the cast of the NBC comedy pilot Brave New World, which was not picked up to series.
Blackburn has also starred as Pete in the six-episode web series Wendy, a project developed by Alloy Entertainment and Macy's that premiered on September 15, 2011. For this occasion, Blackburn recorded a song that was released on August 15, 2011.
In May 2013, it was announced that Blackburn was joining the cast of the Pretty Little Liars spin-off, Ravenswood.
He released his album and started touring in early 2017.
In 2019, Tyler came out as bisexual.
|2006||The Doers of Coming Deeds||Solly Katz||Short|
|2005||Next of Kin||French student|
|2010||Peach Plum Pear||Jesse Pratt|
|2009||Cold Case||Foster / Jeff Feldman||1 episode|
|Rockville, CA||Spencer||1 episode|
|2010||Days of our Lives||Ian||17 episodes|
|2011-2017||Pretty Little Liars||Caleb Rivers||Recurring (season 1-2), Regular (season 3-present)|
|2013||Ravenswood||Caleb Rivers||Spinoff of PLL; cancelled after one season|
|2018||Roswell: New Mexico||Sgt. Alex Manes||Main role|